Across Europe, 30 million people suffer from rare diseases, facing challenges in prevention, diagnosis, and treatment due to fragmented research efforts. To address this, the European Rare Diseases Research Alliance (ERDERA) seeks to make Europe a leader in rare disease research and innovation. ERDERA aims to create a robust ecosystem that prioritises patient needs by enhancing diagnostic methods, integrating digital transformations, and fostering public-private partnerships. This initiative includes a dedicated Clinical Research Network to expedite clinical trials and improve patient care. By aligning strategies across countries and harnessing comprehensive support services, ERDERA is set to accelerate the journey from research to impactful health solutions for rare disease patients throughout Europe.