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Horizon Europe Work Programme Drafts 2026-27: Calls with Relevance to Artificial Intelligence

The final Work Programmes 2026/2027 for Horizon Europe are not yet published, but drafts are available as the European Commission ensures transparency about the discussions in the Programme Committees.

While these cannot yet be published as “calls”, you can find them in the draft documents and there are plenty of them, however, please always check according to the latest available document!

2026-27 Work Programmes (as available from https://sciencebusiness.net/horizon-papers, accessed 2 December 2025):

Examples of draft call topics where “artificial intelligence” contributions are mentioned (illustrative, there are more)

(selected topics from draft work programmes available searching for the term artificial intelligence)

Cluster 1: Health (October version)

  • HORIZON-HLTH-2026-01-STAYHLTH-02: Behavioural interventions as primary prevention for Non-Communicable Diseases (NCDs) among young people
  • HORIZON-HLTH-2026-01-DISEASE-02: Innovative interventions to prevent the harmful effects of using digital technologies on the mental health of children and young adults
  • HORIZON-HLTH-2026-01-DISEASE-03: Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions
  • HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
  • HORIZON-HLTH-2026-01-DISEASE-15: Scaling up innovation in cardiovascular health
  • HORIZON-HLTH-2027-02-DISEASE-01-two-stage: Innovative healthcare interventions for non-communicable diseases
  • HORIZON-HLTH-2027-02-DISEASE-14-two-stage: Clinical trials for advancing innovative interventions for neurodegenerative diseases
  • HORIZON-HLTH-2026-01-CARE-01: Public procurement of innovative solutions for improving citizens’ access to healthcare through integrated or personalised approaches
  • HORIZON-HLTH-2026-01-CARE-03: Identifying and addressing low-value care in health and care systems
  • HORIZON-HLTH-2027-01-CARE-02: Personalised approaches to reduce risks from Adverse Drug Reactions due to administration of multiple medications
  • ORIZON-HLTH-2026-01-TOOL-03: Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing
  • HORIZON-HLTH-2027-02-TOOL-01-two-stage: Development of predictive biomarkers of disease progression and treatment response by using AI methodologies for chronic non-communicable diseases
  • HORIZON-HLTH-2027-03-TOOL-04: Virtual Human Twins (VHTs) for integrated clinical decision support in prevention and diagnosis
  • HORIZON-HLTH-2027-03-TOOL-08: Towards Artificial General Intelligence (AGI) for healthcare
  • HORIZON-HLTH-2026-01-IND-03: Regulatory science to support translational development of patient-centred health technologies
  • HORIZON-HLTH-2027-01-IND-01: Development of cell-free protein synthesis platforms for discovery and/or production of biologicals
  • HORIZON-HLTH-2027-02-IND-02-two-stage: Portable and versatile Point-of-care diagnostics

Cluster 2: Culture, Creativity and Inclusive Society (July version)

  • HORIZON-CL2-2027-01-DEMOCRACY-04: Addressing the impact of artificial intelligence, cyberviolence, and deepfakes on equality, democracy and inclusive societies
  • HORIZON-CL2-2026-01-HERITAGE-02: Boosting creative startups for disruptive innovation
  • HORIZON-CL2-2027-01-HERITAGE-02: AI4Creatives Support Platform: embracing a fair AI revolution
  • HORIZON-CL2-2027-01-TRANSFO-05: The effective use of artificial intelligence in learning environments in pre-primary and primary education
  • HORIZON-CL2-2027-01-TRANSFO-07: Persons with disabilities: opportunities for labour inclusion and social protection through the life course

Cluster 3: Civil security for society (October version)

  • HORIZON-CL3-2027-01-BM-03: Detection and characterisation of threats or illegal/smuggled goods in cargo
  • HORIZON-CL3-2027-01-DRS-02: Societal resilience, engagement of the younger generations and digital innovation for disaster resilience
  • HORIZON-CL3-2027-02-CS-ECCC-01: Artificial Intelligence for Cybersecurity applications
  • HORIZON-CL3-2027-02-CS-ECCC-03: Secure PQC implementations, Cryptanalysis and Post-quantum Digital Trust
  • HORIZON-CL3-2026-01-BM-03: Reliability of age assessment methods in the context of security and border management

Cluster 4: Digital, industry, space (July 2025 version)

  • HORIZON-CL4-2026-01-MATERIALS-PRODUCTION-23: Accelerating the discovery and development of chemicals and innovative advanced materials through digitalisation and artificial intelligence (IA) (Innovative Advanced Materials for the EU partnership)
  • HORIZON-CL4-2027-04-DATA-08: Demand-side 3C pilot demonstrators on converged Telco Edge Cloud Infrastructure (IA)
  • HORIZON-CL4-2026-04-DATA-02: Open Internet Stack Sovereign Solutions (RIA)
  • HORIZON-CL4-2026-04-DATA-03: Open Internet Stack Support for Scale (CSA)
  • HORIZON-CL4-2027-04-DATA-03: New approaches for decentralized, federated and sustainable AI data processing (RIA)
  • HORIZON-CL4-2027-04-DATA-09: Energy efficiency and sustainability of AI data processing in Data Centres (IA)
  • HORIZON-CL4-2026-04-DATA-06: Efficient and compliant access to and use of data (IA)
  • HORIZON-CL4-2026-04-DIGITAL-EMERGING-01: Apply AI: Pilot of the “Science for AI” Pillar of RAISE (“Resource for AI science in Europe”) (RIA)
  • HORIZON-CL4-2027-04-DIGITAL-EMERGING-11: EU Frontier AI Initiative: Developing frontier AI solutions that are safe and computationally efficient within Apply AI (RIA)
  • HORIZON-CL4-2026-05-DIGITAL-EMERGING-02: Next-Generation AI Agents for Real-World Applications in the Apply AI sectors (RIA) (Partnership in AI, Data and Robotics)
  • HORIZON-CL4-2027-04-DIGITAL-EMERGING-04: Apply AI: Challenge-Driven AI Innovation Booster in Apply AI prioritised sectors (RIA) (Partnership in AI, Data and Robotics)
  • HORIZON-CL4-2026-04-DIGITAL-EMERGING-19: Challenge-Driven GenAI4EU Booster (RIA) (AI/Data/Robotics Partnership)
  • HORIZON-CL4-2026-05-DIGITAL-EMERGING-03: Apply AI: Next-Generation Agile and Intelligent Robotics Platforms for Industrial and Service Applications (Partnership in AI, Data and Robotics) (RIA)
  • HORIZON-CL4-2027-04-DIGITAL-EMERGING-05: Apply AI: AI-Driven Robotics for Industry: Enabling System Integration and Adoption (IA) (Partnership in AI, Data and Robotics)
  • HORIZON-CL4-2026-04-DIGITAL-EMERGING-08: Apply AI: Robotics for Manufacturing: Advancing Core Skills through Technical Challenges (RIA) (Partnership in AI, Data and Robotics)
  • HORIZON-CL4-2026-04-DIGITAL-EMERGING-09: Advanced Local Digital Twins using AI for Early Warning and Preparedness (IA)
  • HORIZON-CL4-2027-04-DIGITAL-EMERGING-06: International cooperation in AI (IA)
  • HORIZON-CL4-2026-04-HUMAN-01: Developing and demonstrating core technologies for Virtual Worlds and Web4.0 (IA) (Virtual worlds Partnership)
  • HORIZON-CL4-2027-04-HUMAN-01: Advanced and Innovative hardware components for Virtual Worlds (RIA) (Virtual Worlds Partnership)

Cluster 5: Climate, energy and mobility (October version)

  • HORIZON-CL5-2026-03-D3-03: Innovative technologies and solutions to improve wind energy systems supporting the Strategic Energy Technology (SET) Plan on wind
  • HORIZON-CL5-2027-02-D3-09: Co-funding Strategic Energy Technology (SET) Plan renewable fuel value chains at EU, national, regional, and local level
  • HORIZON-CL5-2027-02-D3-10: Innovative technologies and solutions to improve wave and tidal energy systems
  • HORIZON-CL5-2027-07-D3-12: Demonstration of hydropower technologies for efficient and forward-looking refurbishment of existing hydropower plants
  • HORIZON-CL5-2026-03-D3-19: Grid-forming capabilities for more resilient and RES-based electricity grids
  • HORIZON-CL5-2027-07-D3-26: Advanced TSO control rooms to enhance grid observability, stability and resilience
  • HORIZON-CL5-2027-07-D3-27: Advanced Distribution Management Systems (ADSM) for more efficient and flexible distribution grids
  • HORIZON-CL5-2026-10-D6-03: Generative AI for smarter CCAM: enhancing perception, decision-making, and validation (CCAM Partnership)
  • HORIZON-CL5-2027-06-D6-04: Holistic solutions for CCAM integration in critical scenarios (CCAM Partnership)
  • HORIZON-CL5-2026-10-D6-06: Increasing competitiveness and resilience of multimodal freight transport and logistics for competitive supply chains
  • HORIZON-CL5-2026-03-D3-23: AI-driven forecasting algorithms for Grid and Consumer friendly Energy Sharing – Societal Readiness pilot (18 December 2025 – 31 March 2026)
  • HORIZON-CL5-2027-06-D6-04: Holistic solutions for CCAM integration in critical scenarios (CCAM Partnership) (3 June 2027-7 October 2027)

Cluster 6: Food, bioeconomy, natural resources, agriculture and environment (September version)

  • HORIZON-CL6-2026-02-FARM2FORK-06: Advanced innovative solutions for improved competitiveness and sustainability in controlled environment agriculture (CEA)
  • HORIZON-CL6-2027-02-FARM2FORK-08: AI-powered foodome characterization
  • HORIZON-CL6-2026-01-CIRCBIO-07: Advancing the European bio-based innovation enabled by biotechnology and biomanufacturing concepts
  • HORIZON-CL6-2026-02-CLIMATE-02: Towards the water infrastructures of the future
  • HORIZON-CL6-2027-02-CLIMATE-03: Carbon farming innovation and scale-up
  • HORIZON-CL6-2026-03-GOVERNANCE-01: Additional activities for the Sustainable Blue Economy Partnership (SBEP)
  • HORIZON-CL6-2027-03-GOVERNANCE-04: AI supporting informed advice for farmers and foresters to improve competitiveness and sustainability

Missions (November version)

  • HORIZON-MISS-2027-01-CLIMA-02: Researching and applying the potential of Artificial Intelligence to foster climate resilience at the regional and local levels
  • HORIZON-MISS-2027-02-CANCER-01: Leveraging functional genomics to reveal novel targets for cancer treatment
  • HORIZON-MISS-2026-03-OCEAN-05: Regional (sea-basins) components of the EU Digital Twin Ocean
  • HORIZON-MISS-2026-04-CIT-01: Energy efficient urban and sub-urban public transport, complemented by shared mobility
  • HORIZON-MISS-2027-04-CIT-03: Inclusive and climate resilient multimodal passenger hubs enhancing modal shift towards sustainable transport and shared mobility

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